CYP3A gene variability and cancer cells response to the treatment
نویسندگان
چکیده
The treatment of cancer depends on the activity cytochrome P450 enzyme family, which is essentially carried out by CYP3A4 and CYP3A5 enzymes. aim our study was to investigate whether polymorphism could contribute protein their influence response cells treatment. variability cDNA profiles between cell lines parental HT-29 resistant HT-29-OxR adenocarcinoma detected using denaturing gradient gel electrophoresis (DGGE). Subsequently, sequence analysis CYP3A family members (CYP3A4, CYP3A5) confirmed gene in studied lines. Variations at expression level, level 12 were observed, also different drug treatments line oxaliplatin-resistant HT-29-OxR. might affect efficiency anti-cancer drugs general have an impact metabolism.
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ژورنال
عنوان ژورنال: General Physiology and Biophysics
سال: 2021
ISSN: ['0231-5882', '1338-4325']
DOI: https://doi.org/10.4149/gpb_2020043